Migraine headaches are a huge health problem. In a 2004 report, the World Health Organization (WHO) called migraines and headache disorders a global public health calamity. Migraines and other chronic headache conditions are disabling. In the same report, the WHO ranked migraine as one of the top twenty conditions in the world to cause years of healthy life lost due to disability. Migraines and all other headache disorders combined rank in the top ten causes of disability. As a result of the increasing global recognition of migraine as a health threat, genetic research into the condition has multiplied exponentially in the last ten to fifteen years.
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The Genomics Research Centre at Griffith University, Queensland, Australia, reports progress in locating genetic loci for migraines. Researchers have been studying multi-generational migraine sufferers within the same family for years. According to their website, the researchers have identified three different genetic regions on the chromosomes 1, 19, and X that harbor genes which increase migraine susceptibility. This type of research may eventually lead to a genetic treatment for migraines.
In a study published in June 2003, Dutch doctors revealed that a particular sub-type of migraine, familial hemiplegic migraine, follows a conventional Mendelian inheritance pattern (simple inheritance) in seventy-five percent of all cases. The same study indicated that common migraine is considerably more complex. Several potential genetic loci have been looked at.
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Doctors have long known that a child with two migraineur parent will likely have migraines. A 2000 Danish study using primarily twins indicated that migraine without aura (common migraine) is approximately sixty-one percent genetic. The other thirty-nine percent was attributed to genetic factors, making migraines a partially genetic disease. Family history studies and the Danish study both suggest that migraines are a multi-genomic condition, meaning that several genes or combinations of genes are required for the condition to be inherited. We have to be very flexible when talking to children about Headache. They seem to interpret things in a different way from the way we see things!
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Even if our brain itself is not sensitive to pain, several areas of the skull such as the scalp, face, mouth and throat have nerve fibers that are sensitive to pain and which can hurt. Headache - or cephalgia - ordinarily means any kind of pain that would be felt in those sensitive areas of the skull.
Headaches can be put into two groups: Primary headaches, such as stress headache, cluster...
Headaches
Headaches affect a large proportion of us at one stage in our lives, although degrees will vary. For some of us, headaches can prove so severe that they interfere with our daily routine, leaving us incapacitated for periods. The headache is a condition that is associated with shooting or throbbing pains in the head, although some pain experienced in the lower neck area and back can...
A Tension-type headache is the most common type of primary headache. Many people have 1 or 2 headaches of this type every month. Sometimes they develop more frequently, typically during times of stress. Approximately 3% of people have a tension-type headache on most days. When this happens, the headaches are called chronic tension-type headaches. Tension-type and cluster headaches, and usually...
A confusing situation. A hard exam. A long, tedious talk. In situations like these, a person may normally feel like having a headache. But unfortunately, some people experience more than just a simple headache. Throbbing on an area in your head may be a sign of migraine. But what is migraine and how is it different from a headache?
A headache is described as the pain in the head...
Anti-Serotonin Drugs
Cyproheptadine (Periactin, Perhetine)
This drug blocks the receptors for the neurochemical serotonin in the brain and prevents dilatation of the blood vessels which cause a headache - most important factors in preventing migraine. It also has antihistamine and anti-acetylcholine effects. Its efficacy is low. This drug is often misused in children for...
